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Related Experiment Videos

Normal brain in human newborns: apparent diffusion coefficient and diffusion anisotropy measured by using diffusion

J J Neil1, S I Shiran, R C McKinstry

  • 1Div of Pediatric Neurology, St Louis Children's Hospital, MO 63110, USA.

Radiology
|October 14, 1998
PubMed
Summary
This summary is machine-generated.

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Newborn brain diffusion tensor imaging reveals that water apparent diffusion coefficient (D) decreases with gestational age, while diffusion anisotropy (A sigma) increases near term, offering insights into brain development.

Area of Science:

  • Neuroimaging
  • Pediatric Radiology
  • Biomedical Engineering

Background:

  • Diffusion tensor magnetic resonance (MR) imaging is a powerful tool for assessing brain microstructure.
  • Establishing normative data for developing brains is crucial for identifying abnormalities.

Purpose of the Study:

  • To establish quantitative standards for water apparent diffusion coefficient (D) and diffusion anisotropy (A sigma) in normal newborn brains.
  • To utilize diffusion tensor MR imaging for characterizing early brain development.

Main Methods:

  • Diffusion tensor MR imaging was performed on 22 newborns within 36 hours of birth.
  • Regions of interest were analyzed in various gray and white matter structures.

Main Results:

Related Experiment Videos

  • Newborn D values were higher than adult values and correlated inversely with gestational age.
  • Newborn A sigma values were lower than adult values, with increases noted near term in specific white matter regions.

Conclusions:

  • Water apparent diffusion coefficient (D) reflects overall brain water content.
  • Diffusion anisotropy (A sigma) is sensitive to microstructural changes like myelination and packing.
  • Diffusion tensor imaging provides information not visible on conventional MR sequences.