[Antimicrobial activity of some derivatives of pyrimidine]

In this paper the authors present the antimicrobial and antifungical tests of some new 3-methylpyrimidine compounds. The test was performed using the diffusimetric method with rustlessteel cylinders based on the diffusion of the tested substances on the gelose surface. The comparative analysis of the obtained data leads to the following conclusions concerning the relation between structure and biological activity in the pyrimidine series: 1. The pyrimidinium ylides are less active comparatively with the corresponding salts. That means that the zwitter ionic structure did not favour the activity. 2. Comparative with the corresponding pyridazine(1,2-diazine) derivatives, the pyrimidine(1,3-diazine) compounds are more active. The increase of activity of the pyrimidine compounds could be attributed of the influence of the pyrimidine ring. 3. The most active pyrimidine compound which is tested is that one in which radical R is an amide group. 4. In the case when the radical R is a phenyl ring, the substitute from para position of benzoylic radical does not appear decisive towards activity, these affecting especially the selectivity.