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Synthesis and anticonvulsant activity of some 2-N-(phthalimido)-1-alkyl esters
1Department of Chemical Technology of Drugs, Collegium Medicum, Jagiellonian University, Kraków, Poland.
Die Pharmazie
|October 14, 1998
Abstract:
Synthesis and physicochemical properties of new 2-N-(phthalimido)-1-alkyl esters are described. Esters were synthesized from aromatic and heterocyclic acids with appropriate bromoalkyl phthalimides in the presence of 1,8-diazabicyclo[5,4,0]-undec-7-ene or triethylamine. The obtained compounds were evaluated for anticonvulsant activity. The display protection against MES and ScMet-induced seizures.