Centrally mediated hypocholesterolaemic response of insulin in dogs

Insulin on intravenous administration in dogs caused a rise in blood cholesterol level. This may be due to its direct action on liver or other peripheral structures. On the other hand, insulin administered into the lateral cerebral ventricles in normal as well as in spinal and vagotomized dogs resulted in a lowering of blood cholesterol. In cross circulation studies insulin administered into lateral cerebral ventricles of donor dogs produced a hypocholesterolaemia in the recepient dogs without significant changes in blood cholesterol of donor dogs. It is suggested that some substance may be liberated from some parts of central nervous system due to an action of centrally administered insulin. This substance in turn causes hypocholesterolaemia by acting on liver or some other peripheral structures in dogs.