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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

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[Changes in the ultrastructure of interneuronal connections in experimental chronic morphine poisoning]

Vestnik Rossiiskoi Akademii Meditsinskikh Nauk

|October 15, 1998

Abstract:

To understand the mechanisms of brain activity and behaviour alterations in chronic morphine intoxication, it is especially important to analyze the changes occurring in the interneuronal connections. Analyzing cerebral cortical synapses during morphine treatment revealed that some new synapses formed. The newly formed synapses increased the total number of synapses of the cerebral cortex and reorganized synaptic architectonics. The changes in the synaptic architectonics accompanied ultrastructural changes of dendrites. The development of new synapses and changes of dendrites are the basis for the formation of pathological cerebral cortical systems.

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Articles linked to this work by shared authors, journal, and citation graph.

[REORGANIZATION OF THE ULTRASTRUCTURE OF NEOCORTICAL NEURONS IN RATS TREATED WITH CELL-FREE DNA].

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[Fusion of brain neurons in rat embryos].

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Synaptic plasticity of the neocortex of white rats with diffuse-focal brain injuries.

Neuroscience and behavioral physiology·2006

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Neuroscience and behavioral physiology·2004

[Structural and functional organization of the cerebral cortex neurons in rats with various resistance to emotional stress following administration of delta-sleep-inducing peptide].

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