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Low frequency of recent parvovirus infection in a population-based cohort of patients with early inflammatory
B Harrison1, A Silman, E Barrett
1ARC Epidemiology Research Unit, Manchester.
Objective:
To determine the contribution of human parvovirus B19 infection in explaining the incidence of early inflammatory polyarthritis (IP) in a population.
Setting:
The Norfolk Arthritis Register (NOAR) is a community-based programme aiming to ascertain all new cases of IP arising in a population that lead to attendance at primary care.
Subjects:
147 newly ascertained subjects with IP with a disease duration of less than 16 weeks.
Methods:
Full clinical appraisal of all subjects who were followed up for three years. B19 IgM assayed with a third generation antibody capture enzyme immunoassay.
Results:
Only four (2.7%) patients had evidence of recent B19 infection, only one of whom did not satisfy criteria for rheumatoid arthritis (RA).
Conclusion:
B19 infection does not explain more than a small proportion of either RA or undifferentiated IP cases occurring in the population.
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