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Related Experiment Videos

Remifentanil and tramadol

D J Duthie1

  • 1Department of Anaesthesia, University of Leicester, Glenfield Hospital.

British Journal of Anaesthesia
|October 15, 1998
PubMed
Summary
This summary is machine-generated.

Tramadol is not ideal for severe post-surgery pain alone. It offers fewer side effects than other opioids and NSAIDs, suggesting a potential role in combination therapy for surgical pain management.

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Area of Science:

  • Pharmacology
  • Pain Management
  • Anesthesiology

Background:

  • Severe pain after surgery often requires potent analgesics.
  • Opioids like morphine and codeine, and NSAIDs have significant side effect profiles.
  • Tramadol presents an alternative with a different safety profile.

Purpose of the Study:

  • To evaluate the role of tramadol in managing severe postoperative pain.
  • To compare tramadol's side effect profile with other common analgesics.
  • To explore potential combination strategies for tramadol in pain management.

Main Methods:

  • Review of existing literature on tramadol's efficacy and safety.
  • Comparative analysis of adverse event profiles (respiratory depression, constipation, GI damage, renal impairment).

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  • Assessment of tramadol's utility in multimodal pain management strategies.

    • Main Results:

    • Tramadol demonstrates limited efficacy as a sole agent for severe surgical pain.
    • Tramadol exhibits a lower incidence of respiratory depression and constipation compared to morphine and codeine.
    • Tramadol does not share the asthma, GI, or renal risks associated with NSAIDs.

    Conclusions:

    • Tramadol's limitations as monotherapy for severe postoperative pain are acknowledged.
    • Its favorable side effect profile suggests a potential role in combination with other analgesics like paracetamol.
    • Alternatively, tramadol may be useful after initial severe pain is controlled by regional anesthesia.