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Updated: May 29, 2026
07:33
A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
Chronic intestinal pseudo-obstruction in systemic lupus erythematosus
G Perlemuter1, S Chaussade, B Wechsler
1Service d'Hépatogastroentérologie, Hôpital Cochin, Paris, France.
Gut
|October 15, 1998
Summary
Chronic intestinal pseudo-obstruction (CIPO) in systemic lupus erythematosus (SLE) is a serious condition that can be reversed with treatment. Early diagnosis and intervention are crucial for managing this gastrointestinal complication.
Area of Science:
- Gastroenterology
- Rheumatology
- Internal Medicine
Background:
- Gastrointestinal symptoms are frequent in systemic lupus erythematosus (SLE).
- Chronic intestinal pseudo-obstruction (CIPO), a motility disorder, has not been previously reported in SLE patients.
- This study investigates CIPO in five patients with SLE.
Observation:
- Five patients with SLE or SLE-like syndrome underwent gastrointestinal manometric studies.
- CIPO was the presenting feature in two patients.
- Findings included intestinal hypomotility, reduced bladder capacity, ureteral distension, and esophageal aperistalsis.
Findings:
- Treatment with corticosteroids, parenteral nutrition, pro-motility agents, and antibiotics led to remission of CIPO and urinary abnormalities in all patients.
- Improved intestinal motility was observed post-treatment.
- Intestinal vasculitis was identified as a cause of CIPO in one fatal case.
Implications:
- CIPO in SLE is a life-threatening but reversible condition.
- It can manifest as an early or complicating feature of SLE.
- Potential mechanisms include smooth muscle dysfunction, ureteral/vesical involvement, or intestinal vasculitis.
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