[Mechanisms of the calcium influx across the plasma membrane]
Abstract:
The Ca2+ influx is mainly mediated by voltage-dependent Ca2+ channels and store depletion-dependent Ca2+ channels. The former, which mainly acts to regulate Ca2+ influx in excitable cells, is relatively clear; However, the later, which mainly functions in nonexcitable cells, remains enigmatically complicated. Following activation of the intracellular Ca2+ store, the depletion of the store provides a signal for activating Ca2+ entry across the plasma membrane via presently unknown mechanisms. This paper reviews the rapid progress in this field.
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