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Updated: Sep 17, 2026
Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test
Published on: January 14, 2010
[Behaviour after transplantation of brain cells into monkey models of Parkinson's disease]
1Department of Neurology, Reijing Hospital, Shanghai Second Medical University.
Objective:
To observe the improved degree of pathogenic behaviour in monkey models of Parkinson's disease after transplantation of substantia nigra cells of human fetus.
Method:
1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was used to prepare monkey models of hemiparkinson's disease, i.e., early substantia nigra cells of human fetus were stereotaxically transplanted into PD monkey's behaviour for six months, using immuno-electromicroscopy to prove the transplanted survived neuron.
Results:
After transplantation, the model monkey's motion slow and muscle hypertonia was apparently improved. Limb tremor almost disappeared, Right spontaneous rotation behavior relieved. Rotating frequency caused by APO became less than before transplanytation, and its effect could last a year. Under the immunoelectromicroscope, we observed that transplanted tyrosine hydroxylase positive neuron was connected with the host brain cells in synapse.
Conclusion:
Substantia nigra neuron transplanted into the PD monkey brain can establish synaptic connection with the host nervous cells. Pathogenic symptoms are improved and the effect may remain for a longer time.
