Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

A clinically aggressive, polymorphic, polyclonal posttransplantation lymphoproliferative disorder

C H Dunphy¹, J R Batanian

¹Department of Pathology, St. Louis University Health Sciences Center, MO 63104, USA.

Cancer Genetics and Cytogenetics

|October 17, 1998

Summary

Polymorphic posttransplantation lymphoproliferative disorders (PTLD) can be aggressive even with reduced immunosuppression. Cytogenetic studies may offer prognostic insights when molecular tests show no monoclonality.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study.

Leukemia·2012

Same author

DELETION MAPPING OF CRITICAL REGION FOR HYPOSPADIAS, PENOSCROTAL TRANSPOSITION AND IMPERFORATE ANUS ON HUMAN CHROMOSOME 13.

Journal of pediatric urology·2007

Same author

Successful umbilical cord blood stem cell transplantation in a patient with Rothmund-Thomson syndrome and combined immunodeficiency.

Clinical genetics·2006

Same author

Evaluation of paediatric osteosarcomas by classic cytogenetic and CGH analyses.

Molecular pathology : MP·2002

Same author

Homologous telomere association of 19q in a female with premature ovarian failure.

Clinical genetics·2002

Same author

Acute promyelocytic leukemia, hypogranular variant, with uncharacteristic staining with chloroacetate esterase.

Leukemia & lymphoma·2001

Area of Science:

Immunology
Oncology
Transplantation Medicine

Background:

Posttransplantation lymphoproliferative disorders (PTLD) are categorized by morphology into polymorphic and monomorphic types.
Polymorphic PTLD is generally considered more responsive to immunosuppression reduction.

Observation:

This report details a case of clinically aggressive, polymorphic PTLD that was polyclonal.
The patient's condition persisted despite a reduction in immunosuppressive therapy.

Findings:

The aggressive nature of this polymorphic PTLD challenges the typical treatment response observed in literature.
DNA molecular techniques did not detect monoclonality in this case.

Implications:

This case highlights the need for considering alternative therapeutic strategies for aggressive PTLD.

Related Experiment Videos

Cytogenetic studies may provide valuable prognostic information in PTLD cases where molecular analysis for monoclonality is inconclusive.