Do corneal endothelial dystrophies represent ocular neurocristopathies? A discussion on the available evidence

Current thinking on the embryological origin of human corneal endothelium has it that this cellular population stems from neural crest precursors. There are arguments in support of this assumption but equally persuasive ones against it. We present a discussion of the evidence for and against a neural crest origin for human corneal endothelial cells. In suggesting that caution be applied to extrapolating from non-human work, we would question the fallibility of the current thinking on this subject. To denote human corneal dystrophies as neurocristopathies may be a premature assumption.