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In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells
Published on: September 2, 2019
Molecular chaperone function of the SV40 large T antigen
1Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA.
Abstract:
The SV40 large T antigen (T antigen) is a potent viral oncogene capable of inducing tumours in test animals and transforming cells in culture. T antigen possesses multiple transforming functions that act in a cell-type dependent manner. One of these transforming functions requires a physical association between T antigen and the cellular tumour suppressor p53, while another requires T antigen binding to the retinoblastoma family of tumour suppressors. A third transforming function, <
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