Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Kinase-phosphatase competition regulates Bacillus subtilis development

¹Dept of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA. mperego@scripps.edu

Trends in Microbiology

|October 21, 1998

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Atrial depolarization electrocardiographic features during orthodromic atrioventricular reciprocating tachycardia mediated by right-sided accessory pathway in the dog.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2025

Same author

Inverse probability weighting leads to more accurate incidence estimates for healthcare-associated infections in intensive care units - results from two national surveillance systems.

The Journal of hospital infection·2024

Same author

Use of combined cutting balloon and high-pressure balloon technique for the treatment of double-chambered right ventricle or primary infundibular stenosis: a case series.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2024

Same author

Gene-expression profiling of endomyocardial biopsies from dogs with dilated cardiomyopathy phenotype.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2024

Same author

Noninvasive electrocardiographic parameters to assess interventricular dyssynchrony in dogs with bundle branch blocks.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2022

Same author

Heart rhythm characterization during sudden cardiac death in dogs.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2021

The Bacillus subtilis phosphorelay, a complex regulatory network, controls sporulation initiation by integrating environmental and metabolic signals. It uses opposing protein kinases and phosphatases to precisely manage this crucial developmental process.

Area of Science:

Microbiology
Molecular Biology
Cellular Regulation

Background:

Sporulation initiation in Bacillus subtilis is a critical developmental process.
The phosphorelay system is recognized as the primary regulator of this initiation.
This system integrates diverse signals influencing cell fate.

Purpose of the Study:

To elucidate the regulatory role of the phosphorelay in Bacillus subtilis sporulation.
To understand how the phosphorelay integrates environmental, cell cycle, and metabolic signals.
To describe the sophisticated regulatory network created by opposing kinase and phosphatase activities.

Main Methods:

Analysis of signal transduction pathways.
Biochemical assays for protein kinase and phosphatase activity.

Related Experiment Videos

Genetic studies of Bacillus subtilis sporulation mutants.

Main Results:

The phosphorelay acts as a central hub for signal integration.
Opposing activities of protein kinases and protein aspartate phosphatases are crucial.
A complex regulatory network governs sporulation initiation.

Conclusions:

The phosphorelay is essential for coordinating Bacillus subtilis sporulation.
Signal integration via kinase/phosphatase balance ensures precise developmental timing.
This regulatory network highlights sophisticated cellular control mechanisms.