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Identification of the UL56 protein of herpes simplex virus type 1 within the virion by immuno electron microscopy
R Kehm1, H R Gelderblom, G Darai
1Institut für Medizinische Virologie, Universität Heidelberg, Federal Republic of Germany. J73@IX.URZ.UNI-HEIDELBERG.DE
Abstract:
Recently the UL56 protein of herpes simplex virus type 1 (HSV-1) was shown to be associated with the virion of HSV-1 as determined by Western blot analysis. The detection of the UL56 protein in infected cells and its association with virions of HSV-1 is of particular importance, pointing to a possible involvement of UL56 protein in virus-host interactions. In order to investigate the properties of the UL56 protein further immuno-localization was performed using rabbit hyperimmune serum against fusion recombinant UL56 protein and purified virions of HSV-1 strain F. The UL56 protein was detected in the HSV-1 virions by immuno gold negative staining.