Related Experiment Video
Updated: Jul 2, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Dermatologic manifestations of lupus]
1Service de médecine interne, Groupe hospitalier La Pitié-La Salpêtrière, Paris.
La Revue Du Praticien
|October 22, 1998
Summary
Lupus skin conditions are categorized into lupus lesions, vascular lesions, and other non-lupus lesions. These lupus lesions are further classified as acute, subacute, or chronic, impacting systemic lupus erythematosus presentation.
Area of Science:
- Dermatology
- Rheumatology
- Immunology
Context:
- Cutaneous lupus erythematosus presents diverse clinical and pathological features.
- Understanding these manifestations is crucial for accurate diagnosis and management of systemic lupus erythematosus.
Purpose:
- To categorize and describe the various cutaneous manifestations of lupus.
- To differentiate between acute, subacute, and chronic lupus lesions.
- To outline initial treatment strategies and associated conditions.
Summary:
- Cutaneous lupus encompasses lupus lesions (acute, subacute, chronic), vascular lesions (vasculitis or thrombotic), and rare non-lupus/non-vascular lesions.
- Systemic lupus erythematosus (SLE) exhibits these lesions with variable frequency.
- Antimalarials are the primary treatment for cutaneous lupus lesions, while vascular lesions may indicate antiphospholipid antibodies.
Impact:
- Provides a clear classification of lupus skin conditions for clinicians.
- Highlights the importance of differentiating lesion types for patient management.
- Informs diagnostic and therapeutic approaches in rheumatology and dermatology practices.
Related Concept Videos
01:14Changes in Skin Color: Clinical Perspectives
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:15Reticular Dermis
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
01:24Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...