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Risk factors for new coronary events in older African-American men and women
1Hebrew Hospital Home, Bronx, New York 10475, USA.
Insights
Older African-American men and women share common risk factors for new coronary events, including smoking, hypertension, high total cholesterol, and prior coronary artery disease (CAD). Age and HDL cholesterol also play significant roles.
Area of Science:
- Cardiovascular Disease Epidemiology
- Geriatric Medicine
- Public Health
Background:
- Coronary artery disease (CAD) poses a significant health burden, particularly in older adult populations.
- Understanding specific risk factors within diverse demographic groups, such as older African-Americans, is crucial for targeted prevention strategies.
- Previous research has identified various risk factors for CAD, but specific data for older African-American men and women require further elucidation.
Purpose of the Study:
- To identify and quantify independent risk factors for new coronary events in older African-American men.
- To identify and quantify independent risk factors for new coronary events in older African-American women.
- To compare risk factor profiles between older African-American men and women.
Main Methods:
- Retrospective cohort study design.
- Analysis of data from a cohort of older African-American men and women.
- Statistical modeling to determine independent risk factors and their associated risk ratios for new coronary events.
Main Results:
- For older African-American men, independent risk factors included age, cigarette smoking, hypertension, serum total cholesterol, and prior coronary artery disease (CAD). Serum high-density lipoprotein (HDL) cholesterol showed an inverse association.
- For older African-American women, independent risk factors included cigarette smoking, hypertension, diabetes mellitus, serum total cholesterol, age, and prior CAD. Serum HDL cholesterol also demonstrated an inverse association.
- Risk ratios for key factors like hypertension and prior CAD were notably high in both groups.
Conclusions:
- Cigarette smoking, hypertension, elevated serum total cholesterol, and prior CAD are significant independent risk factors for new coronary events in both older African-American men and women.
- Age is a risk factor for both sexes, while diabetes mellitus is a specific risk factor for women.
- Interventions targeting these modifiable risk factors are essential for reducing the incidence of new coronary events in this population.
Abstract:
Independent risk factors for new coronary events in older African-American men were (1) age (risk ratio = 1.037), (2) cigarette smoking (risk ratio = 2.231), (3) hypertension (risk ratio = 2.531), (4) serum total cholesterol (risk ratio = 1.012), (5) serum high-density lipoprotein (HDL) cholesterol (inverse association) (risk ratio = 0.948), and (6) prior coronary artery disease (CAD) (risk ratio = 2.288). Independent risk factors for new coronary events in older African-American women were (1) cigarette smoking (risk ratio = 2.202), (2) hypertension (risk ratio = 2.344), (3) diabetes mellitus (risk ratio = 1.632), (4) serum total cholesterol (risk ratio = 1.008), (5) serum HDL cholesterol (inverse association) (risk ratio = 0.936), (6) age (risk ratio = 1.026), and (7) prior CAD (risk ratio = 2.368).