Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA recognition by beta-sheets

M Tateno1, K Yamasaki, N Amano

  • 1AIST-NIBHT CREST Centre of Structural Biology, Tsukuba, Japan.

Biopolymers
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of assisted hatching on pregnancy outcomes following 1,678,872 single embryo transfers based on the Japan Assisted Reproductive Technology Registry.

Scientific reports·2025
Same author

Amide proton transfer and chemical exchange saturation transfer MRI differentiates between growing and non-growing intracranial meningiomas: a pilot study.

Clinical radiology·2022
Same author

Investigation of the thermal tolerance of silicon-based lateral spin valves.

Scientific reports·2021
Same author

Quantification of Lung Perfusion Blood Volume by Dual-Energy CT in Patients With and Without Chronic Obstructive Pulmonary Disease.

Journal of the Belgian Society of Radiology·2018
Same author

Predictive models for conversion of prediabetes to diabetes.

Journal of diabetes and its complications·2017
Same author

Impact of weight gain on the evolution and regression of prediabetes: a quantitative analysis.

European journal of clinical nutrition·2016
Same journal

Untreated Rosehip Powder/Poly(Lactic Acid)/Poly(3-Hydroxybutyrate-Co-4-Hydroxybutyrate) Electrospun Mats for Wound Dressing Applications.

Biopolymers·2026
Same journal

Synthesis, Characterization, and Antidiabetic Evaluation of Sequence-Modified Liraglutide Analogs in a Drosophila melanogaster Model.

Biopolymers·2026
Same journal

Fabrication of an Antibacterial Alginate/Chitosan Hydrogel Dressing Loaded With CuO Nanoparticles for Wound Dressing Applications.

Biopolymers·2026
Same journal

Effect of Chitosan-Alginate Polyelectrolyte Complex Formation and Multilayer Polymer Configuration on the Characteristics of 3D-Printed Metronidazole-Loaded Periodontal Films.

Biopolymers·2026
Same journal

Phenolic Grafting of Oxidized Cellulose Nanofibers Using Ferulic Acid: Structural and Antioxidant Analysis Toward Bioactive Nanomaterials.

Biopolymers·2026
Same journal

Detection of a Target Nucleic Acid by Ligation-Assisted Fluorescence Enhancement of a Peptide Nucleic Acid (PNA) Twin Probe via Disulfide Binding.

Biopolymers·2026
See all related articles

Beta-sheets recognize DNA by closely fitting their surfaces to DNA grooves. This detailed analysis reveals how beta-strands interact with major and minor grooves, influencing DNA-protein complex structures.

Area of Science:

  • Structural Biology
  • Molecular Biology
  • Biochemistry

Background:

  • DNA-protein interactions are fundamental to cellular processes.
  • Beta-sheets are common structural motifs in DNA-binding proteins.

Purpose of the Study:

  • To analyze the modes of DNA recognition by beta-sheets.
  • To understand how beta-sheet structure dictates DNA binding geometry.

Main Methods:

  • Analysis of known crystal and solution three-dimensional structures of DNA-protein complexes.
  • Geometric analysis of protein surface and DNA surface complementarity.

Main Results:

  • DNA recognition by beta-sheets is determined by close surface fitting.
  • Beta-strands can follow or cross DNA grooves (major and minor).

Related Experiment Videos

  • Specific curvature and orientation of beta-sheets are required for binding, leading to hyperbolic paraboloidal DNA-binding surfaces.

    • Conclusions:

    • The geometry of beta-sheet binding is dictated by the need for close surface complementarity with DNA.
    • Distinct binding modes are employed for major and minor groove interactions.
    • The resulting DNA-binding surface shape is adapted for specific groove recognition.