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[The effect of rudotel on the synaptic activity of dopaminergic neurons]
E K Podgornaia1, O V Galkina, R Iu Il'iuchenok
1Institute of Inorganic Chemistry, Siberian Branch, Academy of Sciences, Novosibirsk, Russia.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|October 23, 1998
Abstract:
The work discusses the neurochemical correlates of rat brain dopamin-synaptic activity after injection of 0.5 mg/kg rudotel (medazepam) as compared with intact animals. The parameters of functioning of D2-receptors in [3H]-dopamine binding, the content of catecholamines and their metabolites (high-performance liquid chromatography with electrochemical detection) were studied in the dopaminergic system in different brain areas (the striatum, frontal cortex, amygdala, hippocampus, hypothalamus, and accumbence).