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[The effect of thymosin fractions on the development of compression edema-swelling of the brain]

I A Platonov1

  • 1Department of Pharmacology, Smolensk Medical Academy, Russia.

Eksperimental'Naia I Klinicheskaia Farmakologiia
|October 23, 1998
PubMed

The search for pathogenetically drugs for the treatment and prevention of edema-swelling of the brain (ESB) is one of the urgent problems of modern biology and medicine. Immune reactions take part in the development of pathological reactions in ESB formation. The antiedemic action of drugs affecting simultaneously the processes in the nervous and immune systems was studied. Such properties are possessed by regular peptides--thymosin fractions. It was demonstrated on a model that the antiedemic effect of thymic peptides under study was due to the influence of the mediator systems: serotonin and adrenergic. The data obtained allowed the antiedemic mechanism of the effect of thymoptin to be associated with its immunostimulating effect. At the same time, the antiedemic effect of thymalin is not connected directly with the immunostimulating action of the drug.

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