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Reversible oxacillin hepatotoxicity

R N Olans, L B Weiner

    The Journal of Pediatrics
    |November 1, 1976
    PubMed

    Insights

    Oxacillin can cause liver enzyme elevations in patients. Switching to a different penicillin or penicillin G safely resolves these liver function abnormalities.

    Area of Science:

    • Pharmacology
    • Hepatology
    • Infectious Diseases

    Background:

    • Oxacillin is a penicillinase-resistant penicillin antibiotic used for Staphylococcus infections.
    • Drug-induced liver injury is a potential adverse effect of various medications.

    Observation:

    • Eight patients receiving intravenous oxacillin developed elevated hepatic enzymes.
    • Patients were asymptomatic with no jaundice; five showed peripheral eosinophilia.

    Findings:

    • Discontinuation of oxacillin and switching to an alternative penicillinase-resistant penicillin or penicillin G led to rapid normalization of liver enzymes.
    • The observed hepatotoxicity was reversible upon changing the antibiotic regimen.

    Implications:

    • Changing antibiotic therapy is a safe strategy for patients experiencing oxacillin-related hepatotoxicity.
    • This approach allows for the completion of necessary antistaphylococcal treatment without compromising liver function.

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