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Updated: Aug 5, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Debromosceptrin, an alkaloid from the Caribbean sponge Agelas conifera
X Shen1, T L Perry, C D Dunbar
1Department of Pharmacognosy, NCDNP, School of Pharmacy, The University of Mississippi, USA.
Abstract:
As the result of a structurally guided isolation to identify lead compounds for the treatment of opportunistic infections of AIDS, the dihydrochloride salt of a new symmetrical pyrrole dimer debromosceptrin (1), and two known pyrrole analogues (2 and 3) were isolated from the Caribbean sponge Agelas coniferacollected from Belize. The structure of debromosceptrin was identified by analysis of spectral data. 15N spectral data assignments were made for compounds 1-3. Compounds 2 and 3 showed marginal inhibition of Mycobacterium tuberculosis.
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