Related Experiment Videos
Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and
R Q Schaapveld1, J T Schepens, D Bächner
1Department of Cell Biology and Histology, Institute of Cellular Signalling, University of Nijmegen, Adelbertusplein 1, 6525 EK, Nijmegen, The Netherlands.
Abstract:
Using RNA in situ hybridization we compared the expression patterns of the cell adhesion molecule-like receptor-type protein tyrosine phosphatases LAR, RPTP sigma and RPTP sigma during mouse development. We found that LAR is expressed in basal lamina-associated epithelial tissues of (neuro)ectodermal, neural crest/ectomesenchyme and endodermal origin. RPTP sigma is found in (neuro)ectodermal, neural crest-derived systems and in mesoderm-derived tissues. The expression pattern of RPTP sigma largely parallels that of RPTP sigma, in concordance with their proposed evolutionary history