Perinatal characteristics and schizophrenia: electrodermal activity as a mediating link in a vulnerability-stress...

Vulnerability-stress models of schizophrenia assert that the disorder results from an interaction between genetic or biologically acquired vulnerability and unfavourable environmental conditions. As our knowledge of early environmental factors for schizophrenia evolves, the question of links between early factors and a development of schizophrenia becomes more important. In this article, we analyse the relationship between obstetrical complications (OCs) and adult schizophrenia and methodological concerns in the search for pre- and perinatal risk factors. We review findings of aberrant electrodermal activity in schizophrenic patients and suggest that OCs may induce insults to cerebral structures that are critically involved in the control of orienting and of autonomic responses.