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Acute posterior multifocal placoid pigment epitheliopathy following mumps
F X Borruat1, B Piguet, C P Herbort
1Hôpital Ophtalmique Jules Gonin, Lausanne, Switzerland. fborruat@hola.hospvd.ch
Purpose:
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an acquired inflammatory disorder affecting the retina, retinal pigment epithelium, and choroid of healthy adults. APMPPE has been reported to occur after diverse infectious diseases, suggesting a possible immune disorder. The primary site of inflammation remains hypothetical.
Methods/Results:
A previously healthy 37-year-old patient developed APMPPE soon after the onset of mumps. Indocyanine green angiography (ICGA) revealed numerous hypofluorescent lesions throughout the posterior pole, outnumbering the lesions detectable either ophthalmoscopically or on fluorescein angiography. The hypofluorescent lesions visible on ICGA disappeared on follow-up studies.
Conclusion:
This case represents the first reported patient with AMPPE following mumps. Our results suggest that a multifocal choroidopathy might be the underlying cause of APMPPE.
Insights
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) following mumps is presented. Indocyanine green angiography revealed characteristic lesions, suggesting multifocal choroidopathy may underlie APMPPE.
Area of Science:
- Ophthalmology
- Immunology
Background:
- Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an inflammatory condition affecting the retina and choroid.
- Its association with infectious diseases suggests an immune-mediated etiology, but the primary site of inflammation is unclear.
Observation:
- A case of APMPPE following mumps in a 37-year-old patient is described.
- Indocyanine green angiography (ICGA) identified numerous posterior pole hypofluorescent lesions, surpassing those seen with other imaging modalities.
- These ICGA lesions resolved on subsequent examinations.
Findings:
- This report details the first instance of APMPPE occurring after mumps infection.
- ICGA findings suggest a transient multifocal choroidopathy as a potential cause of APMPPE.
Implications:
- This case expands the known triggers for APMPPE.
- It supports the hypothesis that APMPPE may stem from an underlying multifocal choroidopathy, potentially triggered by viral infections.