The SCN is comprised of a population of coupled oscillators

The circadian clock in the suprachiasmatic nucleus (SCN) of the mammalian hypothalamus exhibits two necessary properties: (1) a mechanism for the generation of autonomous circadian rhythms in individual pacemaker cells, and (2) a means to synchronize the autonomous pacemaker cells. A variety of potential components of the endogenous pacemaker, including ion channels, second messengers, transcriptional factors, and the protein targets of kinases and transcription factors are reviewed. Similarly, reverse transmitter transport, extracellular ion fluxes, small membrane-diffusible molecules, glial regulation, and neural adhesion molecules are considered as possible synchronizing factors. Provisional criteria are suggested for empirical distinction of endogenous pacemaker versus synchronizing mechanisms.