Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Long-term bone response to particulate injectable ceramic

A Dupraz1, J Delécrin, A Moreau

  • 1UPRES EA 2159, Faculté de chirurgie dentaire, Nantes, France. anne.dupraz@wanadoo.fr

Journal of Biomedical Materials Research
|October 27, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Comprehensive DNA Barcode Reference Library for the Macroinvertebrates of Scottish Seagrass Beds Using Oxford Nanopore Flongle Flowcells.

Ecology and evolution·2025
Same author

Does the Autologous Matrix-Induced Chondrogenesis (AMIC®) technique result in positive outcomes for the repair of cartilage lesions in the knee in adolescent patients? Preliminary results at 2,6 years average follow-up.

Acta orthopaedica Belgica·2025
Same author

Arrhythmogenic cardiomyopathy as a myogenic disease: highlights from cardiomyocytes derived from human induced pluripotent stem cells.

Frontiers in physiology·2023
Same author

Ablating Ion Velocity Distributions in Short-Pulse-Heated Solids via X-Ray Doppler Shifts.

Physical review letters·2022
Same author

Clinical considerations for DPD deficiency testing in advanced cancer patients: tumor lysis syndrome should be considered as a major interference.

Annals of oncology : official journal of the European Society for Medical Oncology·2022
Same author

Resonant dielectric multilayer with controlled absorption for enhanced total internal reflection fluorescence microscopy.

Optics express·2022
Same journal

Optimizing the tensile properties of polyvinyl alcohol hydrogel for the construction of a bioprosthetic heart valve stent.

Journal of biomedical materials research·2002
Same journal

Wear of conventional and cross-linked ultra-high-molecular-weight polyethylene acetabular cups against polished and roughened CoCr femoral heads in a biaxial hip simulator.

Journal of biomedical materials research·2002
Same journal

Immobilization of natural macromolecules on poly-L-lactic acid membrane surface in order to improve its cytocompatibility.

Journal of biomedical materials research·2002
Same journal

Light scattering and in vitro biocompatibility studies of poly (vinyl pyrrolidone) derivatives with amino-acid-dependent groups.

Journal of biomedical materials research·2002
Same journal

Immobilization of an oxalate-degrading enzyme on silicone elastomer.

Journal of biomedical materials research·2002
Same journal

An evaluation of the cytotoxic effects of orthodontic bonding adhesives upon a primary human oral gingival fibroblast culture and a permanent, human oral cancer-cell line.

Journal of biomedical materials research·2002
See all related articles

Biphasic calcium phosphate particles (BCP) and composite materials (COMP) show similar bone ingrowth but varying inflammatory responses and degradation rates in rabbit femurs over 78 weeks.

Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Cellular Biology

Background:

  • Biphasic calcium phosphate (BCP) particles are widely used in bone regeneration.
  • Injectable composite materials (COMP) offer potential advantages for bone defect filling.
  • Understanding the long-term biological response is crucial for clinical application.

Purpose of the Study:

  • To evaluate the long-term biological response of BCP particles and a COMP in rabbit femoral defects.
  • To compare bone ingrowth, inflammatory reaction, and material degradation between BCP and COMP.

Main Methods:

  • Biphasic calcium phosphate particles (BCP) and a composite material (COMP) were implanted in rabbit femurs.
  • Long-term follow-up up to 78 weeks.
  • Histological analysis of inflammatory response, bone ingrowth, and material degradation.

Related Experiment Videos

Main Results:

  • Both BCP and COMP induced a foreign-body reaction with macrophage-mediated phagocytosis, stronger for COMP.
  • No significant difference in bone ingrowth was observed between BCP and COMP.
  • COMP showed more severe degradation, particularly in the initial 4 weeks, likely due to smaller particle size.

Conclusions:

  • BCP and COMP are biocompatible materials promoting bone ingrowth with manageable inflammatory responses.
  • COMP exhibits faster degradation, potentially influenced by its finer mineral phase granulometry.
  • Cell-mediated degradation of calcium phosphate particles continues throughout the 78-week study period.