Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene recognition by combination of several gene-finding programs

K Murakami1, T Takagi

  • 11Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai Minato-ku, Tokyo 108-8639 and 2Central Research Laboratory, Hitachi Ltd, 1-280 Higashi-Koigakubo, Kokubunji-shi, Tokyo 185-8601, Japan.

Bioinformatics (Oxford, England)
|October 28, 1998
PubMed
Summary

Combining multiple eukaryotic gene-finding programs improves accuracy. Re-analyzing and merging results using HIGHEST-policy or BOUNDARY methods enhanced approximate correlation (AC) by 3-5% over single programs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of ascorbic acid and ascorbic acid 2-O-alpha-glucoside on the cytotoxicity and bioavailability to low density cultures of fibroblasts.

Biochemical pharmacology·1992
Same author

Species-specific kinetics of mouse renin contribute to maintenance of normal blood pressure in transgenic mice with overexpressed human angiotensinogen.

The Journal of veterinary medical science·1992
Same author

[Growth factors: a regulator of renal function].

Nihon rinsho. Japanese journal of clinical medicine·1992
Same author

A carboxyl-terminal truncated version of the activin receptor mediates activin signals in early Xenopus embryos.

FEBS letters·1992
Same author

Distribution of the piriform cortical terminals to cells in the central segment of the mediodorsal thalamic nucleus of the rat.

Brain research·1992
Same author

Cloning and characterization of genes involved in the biosynthesis of delta-aminolevulinic acid in Escherichia coli.

Gene·1992

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Predicting eukaryotic gene structures from DNA is crucial but challenging.
  • Existing gene-finding programs have limitations in accuracy and reliability.

Purpose of the Study:

  • To improve eukaryotic gene structure prediction accuracy.
  • To evaluate methods for combining results from multiple gene-finding programs.

Main Methods:

  • Comparative analysis of four gene-finding programs: FEXH, GeneParser3, GEN-SCAN, and GRAIL2.
  • Application of HIGHEST-policy and BOUNDARY combination methods.
  • Evaluation using OR-based combination for exon overlap detection.

Main Results:

  • The HIGHEST-policy and BOUNDARY combination methods improved approximate correlation (AC) by 3-5% compared to the best single program.

Related Experiment Videos

  • OR-based combination demonstrated high reliability for identifying overlapping exons.
  • The developed methods are extensible to incorporate additional gene-finding programs.

    • Conclusions:

    • Combining gene-finding programs offers a significant improvement in eukaryotic gene structure prediction.
    • The HIGHEST-policy, BOUNDARY, and OR-based combination strategies provide effective approaches for enhancing gene prediction accuracy and reliability.