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Subungual myxoid pleomorphic fibroma
A Hassanein1, G Telang, E Benedetto
1Department of Dermatology, Allegheny University of the Health Sciences (Hahnemann Campus), Philadelphia, Pennsylvania, USA.
The American Journal of Dermatopathology
|October 28, 1998
Summary
This study describes a rare case of pleomorphic fibroma, a benign skin tumor, found in the subungual space of a thumb. This finding is significant as it
Area of Science:
- Dermatopathology
- Surgical Pathology
Background:
- Pleomorphic fibroma is a rare benign mesenchymal neoplasm.
- It typically presents as a soft tissue tumor in various body locations.
- Subungual space involvement by this entity is exceptionally uncommon.
Observation:
- A 54-year-old male presented with symptoms mimicking paronychia and a thickened nail.
- A subungual lesion, initially suspected as pyogenic granuloma, was surgically removed.
- Histopathological examination revealed a hypocellular fibroma with atypical fibroblasts and giant cells.
Findings:
- The subungual lesion exhibited characteristic features of pleomorphic fibroma.
- Immunohistochemistry showed strong CD34 and vimentin positivity in atypical cells.
- The tumor cells were negative for S-100 protein and actin.
Implications:
- This case highlights the subungual space as a novel, albeit rare, site for pleomorphic fibroma.
- Accurate histopathological diagnosis is crucial for differentiating from other subungual lesions.
- Understanding the immunohistochemical profile aids in classifying this rare tumor.