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Related Experiment Videos

Sympathetic skin response in myelopathies

K P Nair1, A B Taly, G R Arunodaya

  • 1Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India.

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
|October 29, 1998
PubMed
Summary

Sympathetic skin response (SSR) is often abnormal in spinal cord disorders. Preserved palmar SSR in myelopathy patients may predict good motor recovery and bladder function, aiding prognosis.

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Area of Science:

  • Neuroscience
  • Clinical Electrophysiology
  • Autonomic Nervous System Research

Background:

  • Autonomic dysfunctions are common and serious complications in spinal cord disorders, impacting patient morbidity and mortality.
  • Sympathetic skin response (SSR) is a noninvasive electrophysiological test that can assess sympathetic nervous system function.
  • Evaluating SSR in myelopathy patients may offer insights into autonomic impairment and clinical outcomes.

Purpose of the Study:

  • To investigate the utility of Sympathetic Skin Response (SSR) in patients diagnosed with myelopathy.
  • To correlate SSR findings with clinical characteristics, lesion severity, somatosensory evoked potentials (SSEP), and patient outcomes.
  • To determine if SSR can serve as a prognostic indicator in spinal cord disorders.

Main Methods:

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  • Thirty myelopathy patients underwent electrophysiological assessments, including SSR and SSEP.
  • SSR was recorded from palm and sole following stimulation of the supraorbital, median, and posterior tibial nerves.
  • SSEP was recorded from the scalp after median and posterior tibial nerve stimulation.

Main Results:

  • Absent SSR from the sole was observed in 25 patients, and from the palm in 10 patients.
  • Absent SSR from the palm correlated with poorer outcomes, while preserved palmar SSR with posterior tibial nerve stimulation indicated better outcomes and bladder sensation.
  • Absent SSR from the sole did not show significant correlation with clinical features, bladder dysfunction, or prognosis.

Conclusions:

  • Sympathetic skin response is frequently abnormal in patients with myelopathies, indicating autonomic pathway involvement.
  • Preserved palmar SSR following posterior tibial nerve stimulation may be a valuable predictor of good motor recovery and preserved bladder sensation.
  • SSR serves as a useful adjunct tool for evaluating patients with spinal cord disorders and predicting outcomes.