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Adhesion molecules in clinical medicine
J D Cavenagh1, M R Cahill, S M Kelsey
1Dept. of Haematology, Royal London Hospital, UK.
Critical Reviews in Clinical Laboratory Sciences
|October 29, 1998
Summary
Cellular adhesion molecules (CAMs) are vital for development, repair, and immune responses. Targeting CAMs with monoclonal antibodies shows promise for treating inflammatory diseases, thrombosis, and graft rejection.
Area of Science:
- Immunology
- Cell Biology
- Biochemistry
Background:
- Cellular adhesion molecules (CAMs) are crucial for embryogenesis, tissue repair, lymphocyte function, and metastasis.
- CAMs mediate interactions between hemopoietic progenitors and the bone marrow, and between blood cells and the vascular endothelium.
- Expression of CAMs influences normal hemopoiesis, mature cell migration, and inflammatory responses, potentially regulating cytokine synthesis and tumorigenesis.
Purpose of the Study:
- To review the critical roles of CAMs in various physiological and pathological processes.
- To highlight the significance of CAM expression in hemopoiesis, inflammation, and tumorigenesis.
- To discuss the therapeutic potential of monoclonal antibodies targeting CAMs.
Main Methods:
- Literature review of studies on cellular adhesion molecules.
- Analysis of the role of CAMs in developmental and disease processes.
- Examination of preclinical and clinical data on monoclonal antibody therapies targeting CAMs.
Main Results:
- CAMs are essential for cell-cell interactions in development, immunity, and disease.
- CAM expression is implicated in hemopoiesis, inflammation, and cancer progression.
- Monoclonal antibodies against CAMs demonstrate potential in managing inflammation, thrombosis, and immune-related disorders.
Conclusions:
- Cellular adhesion molecules play multifaceted roles in health and disease.
- Targeting CAMs offers a promising therapeutic strategy for various clinical conditions.
- Further research into CAMs and their antibodies could lead to novel treatments for inflammatory and metastatic diseases.