Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apolipoprotein E and longevity among Han Chinese population

Z Jian-Gang1, M Yong-Xing, W Chuan-Fu

  • 1Section of Human Genome Project, Shanghai Research Center of Life Sciences, Chinese Academy of Sciences, People's Republic of China.

Mechanisms of Ageing and Development
|October 29, 1998
PubMed
Summary

The apolipoprotein E (APOE) gene

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infrared intracavity laser absorption spectroscopy with a continuous-scan Fourier-transform interferometer.

Applied optics·2008
Same author

Modified in-line Sagnac interferometer with passive demodulation technique for environmental immunity of a fiber-optic current sensor.

Applied optics·2008
Same author

Education and imaging. Gastrointestinal: bleeding gastric diverticulum.

Journal of gastroenterology and hepatology·2008
Same author

Simple high-coherence rapidly tunable external-cavity diode laser.

Optics letters·2007
Same author

BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor.

Oncogene·2007
Same author

Prostacyclin protects renal tubular cells from gentamicin-induced apoptosis via a PPARalpha-dependent pathway.

Kidney international·2007

Area of Science:

  • Genetics and Aging Research
  • Human Population Genetics

Background:

  • The apolipoprotein E (APOE) gene, with common alleles APOE*2, APOE*3, and APOE*4, is linked to longevity in Western populations.
  • Allele frequencies of APOE vary significantly across different ethnic groups.

Purpose of the Study:

  • To investigate the association between APOE alleles and longevity in the Han Chinese population.
  • To determine if APOE*4 allele frequency differs across various age groups in this specific demographic.

Main Methods:

  • Genotyping of the APOE gene in 1562 Han Chinese individuals aged 20-108 years.
  • Utilized polymerase chain reaction (PCR) for APOE amplification.
  • Analyzed PCR products using CfoI digestion and polyacrylamide gel electrophoresis to determine allele frequencies.

Related Experiment Videos

Main Results:

  • The allele frequency of APOE*4 was significantly lower in the very old age group (≥85 years) compared to younger age groups (20-39, 40-59, and 60-84 years).
  • Observed APOE*4 frequencies: 2.5% in the oldest group vs. 8.4%, 7.9%, and 7.6% in the youth, middle, and old age groups, respectively (P < 0.05).

Conclusions:

  • The APOE*4 allele frequency shows a significant inverse association with extreme longevity in the Han Chinese population studied.
  • Findings suggest that the role of APOE in longevity may be population-specific and warrants further investigation in diverse ethnic groups.