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[Euthyroid sick syndrome: recent physiopathologic findings]

B Goichot1, R Sapin, J L Schlienger

  • 1Service de médecine interne, hôpital de Hautepierre, Strasbourg, France.

La Revue De Medecine Interne
|October 30, 1998
PubMed
Summary

Euthyroid sick syndrome, common in nonthyroidal illness, involves altered thyroid hormone (T3) levels. Understanding its regulation and transport proteins is key to unraveling this complex endocrine response.

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Clinical presentation of hyperthyroidism in a large representative sample of outpatients in France: relationships with age, aetiology and hormonal parameters.

Clinical endocrinology·2015

Area of Science:

  • Endocrinology
  • Molecular Biology

Context:

  • Nonthyroidal illness frequently causes abnormal thyroid function tests, termed euthyroid sick syndrome.
  • The clinical significance remains unclear, with hypotheses including abnormal endocrine response or adaptive stress mechanisms.
  • Recent research explores deiodinase activity, thyroid hormone transport, cytokines, and nutritional factors in its pathogenesis.

Purpose:

  • To investigate the underlying mechanisms of euthyroid sick syndrome.
  • To clarify the role of deiodinase, hormone transport, cytokines, and nutritional factors.
  • To understand the regulation of thyroid hormone metabolism in critical illness.

Summary:

  • Euthyroid sick syndrome is characterized by reduced tissue triiodothyronine (T3) levels.
  • Factors like cytokines and nutritional status influence thyroid hormone metabolism, but mechanisms are not fully elucidated.
  • The role of hepatic deiodinase in starvation-induced T3 decrease is under re-evaluation.

Impact:

  • Euthyroid sick syndrome serves as a model for studying thyroid hormone metabolism regulation.
  • Characterizing thyroid hormone transport proteins is crucial for advancing understanding of this syndrome.
  • Insights may improve management of patients with critical illness and abnormal thyroid tests.

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