Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Global primary blast injury: a rat model

R J Irwin1, M R Lerner, J F Bealer

  • 1Department of Pediatric Surgery, Oklahoma City 73190, USA.

The Journal of the Oklahoma State Medical Association
|October 30, 1998
PubMed
Summary

A new rodent model accurately replicates bomb blast injuries in a controlled lab setting. This model aids in understanding blast wave injury pathophysiology and developing treatments for victims.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adolescent alcohol exposure produces sex differences in negative affect-like behavior and group I mGluR BNST plasticity.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2020
Same author

Canadian integrated program for antimicrobial resistance surveillance: Retail food highlights, 2003-2012.

Canada communicable disease report = Releve des maladies transmissibles au Canada·2018
Same author

Ciprofloxacin-resistant <i>Campylobacter</i> in broiler chicken in Canada.

Canada communicable disease report = Releve des maladies transmissibles au Canada·2018
Same author

Impaired glucose tolerance attenuates bone accrual by promoting the maturation of osteoblasts: Role of Beclin1-mediated autophagy.

Bone reports·2017
Same author

Ki-67 Expression in a Cervical Cancer Organotypic Model Correlates with Growth and EGF-R Expression.

Journal of lower genital tract disease·2015
Same author

A simple model for adaptive variation in the sex ratios of mammalian offspring.

Journal of theoretical biology·2009

Area of Science:

  • Trauma research
  • Physiology
  • Biomedical engineering

Background:

  • Blast wave injuries are complex and poorly understood.
  • Previous blast models lacked controlled laboratory conditions and sophisticated monitoring.
  • A need exists for a reproducible model to study blast wave effects.

Purpose of the Study:

  • To characterize a novel rodent model for global blast injury.
  • To establish a safe and controlled laboratory environment for blast wave research.
  • To provide a tool for studying blast injury pathophysiology and treatment.

Main Methods:

  • Male rats were randomized into four groups (n=10 each).
  • Rats were exposed to controlled blast waves (80-120 psi, 1-2 msec) at varying distances.

Related Experiment Videos

  • Physiological responses and injuries were monitored post-blast.

    • Main Results:

    • Blast exposure caused immediate, transient bradycardia.
    • Mean arterial pressure showed a bimodal pattern with severe hypotension.
    • Characteristic injuries including pulmonary hemorrhage and hemoperitoneum were observed.

    Conclusions:

    • The developed rodent model effectively reproduces clinical blast wave injuries.
    • This model offers a powerful platform for investigating blast injury mechanisms.
    • The model will facilitate the development of potential therapeutic strategies for blast victims.