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Flumethasone-induced insulin resistance in calves
K Sternbauer1, J Luthman, S O Jacobsson
1Faculty of Veterinary Medicine, Department of Ruminant Medicine and Veterinary Epidemiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Zentralblatt Fur Veterinarmedizin. Reihe A
|October 30, 1998
Summary
A single dose of flumethasone significantly reduced insulin sensitivity and glucose utilization in calves by 74% within 24 hours. Insulin sensitivity returned to normal levels by 72 hours post-treatment.
Area of Science:
- Veterinary Medicine
- Endocrinology
- Pharmacology
Background:
- Glucocorticoids, like flumethasone, are widely used for their anti-inflammatory properties.
- Understanding the metabolic side effects of therapeutic doses is crucial for animal health.
- Insulin resistance can have significant implications for animal metabolism and disease.
Purpose of the Study:
- To investigate the acute effects of a single therapeutic dose of flumethasone on insulin sensitivity in calves.
- To quantify changes in glucose utilization following flumethasone administration.
Main Methods:
- Calves were administered a single therapeutic dose of flumethasone (0.5 mg/100 kg b.w.).
- Hyperinsulinemic, euglycemic clamp tests were conducted before and at 24 and 72 hours after treatment.
- Insulin-dependent glucose utilization was measured as the primary outcome.
Main Results:
- A single dose of flumethasone significantly reduced insulin-dependent glucose utilization by 74% at 24 hours post-treatment (P < 0.005).
- No significant alterations in glucose utilization were observed at 72 hours post-treatment.
Conclusions:
- Flumethasone, at a therapeutic dose, induces transient insulin resistance in calves.
- These findings highlight a short-term metabolic side effect of flumethasone treatment in cattle.
- Monitoring glucose metabolism may be warranted in calves treated with flumethasone.