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Related Experiment Videos

Opioid detoxification in pregnancy

J S Dashe1, G L Jackson, D A Olscher

  • 1Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235-9032, USA.

Obstetrics and Gynecology
|October 30, 1998
PubMed
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Antepartum opioid detoxification is safe for selected pregnant women. This study found no fetal distress or death, with only 15% of neonates requiring treatment for withdrawal.

Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Abstinence Syndrome
  • Addiction Medicine

Background:

  • Opioid withdrawal during pregnancy is linked to adverse fetal outcomes like poor growth and preterm birth.
  • Evaluating the safety of detoxification is crucial for managing opioid-dependent pregnancies.

Purpose of the Study:

  • To assess the safety and feasibility of inpatient opioid detoxification during pregnancy in selected women.

Main Methods:

  • Inpatient detoxification offered to pregnant women with opioid use (1990-1996).
  • Sonography used to confirm gestational age and rule out fetal growth restriction/oligohydramnios.
  • Clonidine or methadone used for withdrawal management; antenatal testing initiated at 24 weeks.

Main Results:

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  • 34 women underwent detoxification, with a median gestational age of 24 weeks.
  • 59% successfully detoxified without relapse; 29% resumed opioid use; 12% opted for methadone maintenance.
  • No fetal distress, fetal death, or delivery before 36 weeks observed; 15% of neonates treated for withdrawal.

Conclusions:

  • Antepartum opioid detoxification can be safely achieved in carefully selected pregnant individuals.
  • This approach may offer a viable alternative to methadone maintenance for some opioid-using pregnant women.