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Addressing the challenges to immunization practice with an economic algorithm for vaccine selection

B G Weniger1, R T Chen, S H Jacobson

  • 1National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. bgw2@cdc.gov

Vaccine
|October 31, 1998
PubMed
Summary
This summary is machine-generated.

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Purchasing vaccines involves complex decisions beyond just price. An economic algorithm was developed to minimize disease control costs by considering multiple factors, offering better value and encouraging vaccine innovation.

Area of Science:

  • Biotechnology and Public Health
  • Health Economics and Policy

Background:

  • The growing number of available vaccines presents challenges for purchasers, who often base selection solely on purchase price.
  • Current vaccine purchasing decisions lack systematic consideration of various fiscal factors beyond initial cost.

Purpose of the Study:

  • To develop an economic algorithm for vaccine selection that minimizes overall disease control costs through immunization.
  • To incorporate multiple factors beyond purchase price into vaccine selection decisions.

Main Methods:

  • Developed a pilot binary-integer linear programming model considering purchase price, doses, preparation time, and route of administration.
  • Modeled recommended immunization schedules for diphtheria, tetanus, pertussis, Haemophilus influenzae b, and hepatitis B.

Related Experiment Videos

  • Utilized actual vaccine prices and estimated costs for new vaccines to test the algorithm.

    • Main Results:

    • The algorithm identified lowest-cost vaccine stocking lists, with costs ranging from $450.32 to $529.41 per child depending on assumptions.
    • The most economical vaccine selections were not intuitively predictable due to numerous permutations and sensitivity to cost changes.
    • Ensuring manufacturer diversity increased costs by approximately $13.00 and required an additional injection.

    Conclusions:

    • An objective selection method considering economic value of vaccine features can provide 'best value' to purchasers.
    • Such a method can incentivize innovation and competition within the vaccine industry.
    • Systematic economic evaluation is crucial for optimal vaccine procurement and public health outcomes.