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[Pulmonary function at the early stage after bone marrow transplantation]
1First Department of Internal Medicine, Nihon University School of Medicine.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 31, 1998
Summary
Bone marrow transplantation (BMT) can lead to progressive declines in lung function, specifically vital capacity and diffusing capacity, even in asymptomatic patients. These pulmonary changes may occur earlier in those with graft-versus-host disease or high-dose total body irradiation.
Area of Science:
- Pulmonology
- Hematology
- Transplantation Medicine
Context:
- Bone marrow transplantation (BMT) is a critical treatment for various hematologic and oncologic conditions.
- Pulmonary complications following BMT can significantly impact patient outcomes.
- Monitoring lung function in BMT recipients is essential for early detection of adverse effects.
Purpose:
- To prospectively evaluate changes in pulmonary function in patients undergoing BMT.
- To identify factors associated with earlier declines in lung function post-BMT.
- To assess the impact of graft-versus-host disease (GVHD) and total body irradiation (TBI) on lung function.
Summary:
- Twenty-one patients (aged 16-41) were monitored for pulmonary function up to nine months after BMT.
- While initial lung function tests (FEV1.0%, V25, V50/V25) were normal, percent vital capacity (%VC) and percent diffusing capacity of lung for CO (% DLco) showed progressive declines in most patients.
- Earlier pulmonary function decline was observed in patients with GVHD and those receiving high-dose rate or high lung dose TBI.
Impact:
- Highlights subclinical pulmonary function changes after BMT.
- Identifies GVHD and TBI as risk factors for pulmonary complications.
- Emphasizes the importance of frequent pulmonary function testing in BMT patients for early intervention.