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Comment on the cylindrical capacitor electrospray interface

S König, H M Fales, K D Haegele

Analytical Chemistry

|October 31, 1998

Summary

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A new electrospray interface, proposed by Wang and Hackett, achieved excellent spectra. However, similar results can be obtained simply by ensuring direct electrical contact, negating the need for a capacitor effect.

Area of Science:

Analytical Chemistry
Mass Spectrometry

Background:

A novel electrospray interface termed a "concentric cylindrical capacitor" was recently proposed.
This interface demonstrated excellent spectral quality, particularly in negative ion mode, for various analytes including lipid A, oligonucleotides, and proteins.

Purpose of the Study:

To investigate the necessity of the "concentric cylindrical capacitor" design for achieving high-quality electrospray ionization mass spectrometry (ESI-MS) spectra.
To determine if simplified direct electrical contact can yield comparable results.

Main Methods:

Electrospray ionization mass spectrometry (ESI-MS) was employed.
Analyte solutions were introduced via a fused-silica capillary.
Direct electrical contact was established between the capillary and the high-voltage supply, bypassing the proposed capacitor interface.

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Main Results:

High-quality mass spectra were obtained using the simplified direct electrical contact method.
The results were comparable to those reported for the concentric cylindrical capacitor interface.
Excellent spectra were achieved for lipid A, a 15-mer oligonucleotide, and proteins, especially in negative ion mode.

Conclusions:

The proposed "concentric cylindrical capacitor" electrospray interface is not essential for obtaining excellent ESI-MS spectra.
Direct electrical contact between the analyte capillary and the high-voltage supply is sufficient for high-quality spectral acquisition.
This finding simplifies the setup for electrospray ionization, making it more accessible.