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Prothrombin fragment 1+2 is a risk factor for myocardial infarction in treated hypertensive men
S Agewall1, J Wikstrand, B Fagerberg
1Department of Medicine, Sahlgrenska University Hospital, Göteborg University, Sweden.
Insights
Prothrombin fragment 1+2 and C-reactive protein levels predict major coronary events in hypertensive men. These hemostatic factors also predict mortality, highlighting their importance in cardiovascular disease risk.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Biomarkers
Background:
- Hemostatic factors are implicated in acute coronary heart disease development.
- Understanding these factors is crucial for predicting cardiovascular events.
Purpose of the Study:
- To assess fibrinogen, von Willebrand factor, prothrombin fragment 1+2, thrombin-antithrombin complex, plasminogen activator inhibitor activity, and C-reactive protein as predictors of major coronary events.
- To evaluate these markers' association with mortality in a cohort of hypertensive men.
Main Methods:
- A cohort of 131 men (aged 56-77) with treated hypertension and additional cardiovascular risk factors were studied.
- Mean follow-up duration was 3.0 years, with monitoring for major coronary events (myocardial infarction, sudden death) and mortality.
- Statistical adjustments were made for other known cardiovascular risk factors.
Main Results:
- Prothrombin fragment 1+2 and C-reactive protein emerged as independent predictors of major coronary events.
- Fibrinogen and prothrombin fragment 1+2 levels were identified as independent predictors of mortality.
- Other measured hemostatic variables did not show significant associations with major coronary events.
Conclusions:
- Prothrombin fragment 1+2 and C-reactive protein levels are significant independent predictors of major coronary events in treated hypertensive men.
- These biomarkers may aid in risk stratification for cardiovascular events and mortality in this population.
Background:
Haemostatic factors may play a part in the development of acute coronary heart disease.
Objective:
To evaluate as predictors of major coronary events (fatal and non-fatal myocardial infarctions and sudden death) levels of fibrinogen, von Willebrand factor, prothrombin fragment 1+2, thrombin-antithrombin complex, plasminogen activator inhibitor activity and C-reactive protein.
Methods:
We studied 131 men, aged 56-77 years, with treated hypertension and at least one additional cardiovascular risk factor (hypercholesterolaemia, diabetes mellitus or smoking). These patients were recruited from a continuing risk factor intervention study. The mean observation time was 3.0 years.
Results:
Fourteen patients died and 16 had a major coronary event during the follow-up period. After adjustments for other risk factors, levels of prothrombin fragment 1+2 and C-reactive protein were independent predictors of major coronary events. The other measured haemostatic variables were not significantly associated with major coronary events during follow-up. Fibrinogen and prothrombin fragment 1+2 levels were independent predictors for mortality.
Conclusions:
Among treated hypertensive men, levels of prothrombin fragment 1+2 and C-reactive protein were independent predictors of major coronary events.