Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renographic indices for evaluation of changes in graft function

T A El-Maghraby1, J W de Fijter, B L van Eck-Smit

  • 1Division of Nuclear Medicine, Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.

European Journal of Nuclear Medicine
|November 3, 1998
PubMed
Summary

Quantitative radionuclide renography is crucial for assessing early kidney transplant function. While specific parameters show promise in monitoring graft recovery, they cannot definitively distinguish between acute tubular necrosis and acute rejection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes in numbers needed to treat and hospital care expenditures of optimized indications for primary prevention implantable cardioverter defibrillators: a scenario analysis.

Clinical research in cardiology : official journal of the German Cardiac Society·2025
Same author

Regularized parametric survival modeling to improve risk prediction models.

Biometrical journal. Biometrische Zeitschrift·2023
Same author

A European-Japanese study on peach allergy: IgE to Pru p 7 associates with severity.

Allergy·2023
Same author

Hospital utilisation and the costs associated with complications of ICD implantation in a contemporary primary prevention cohort.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2022
Same author

Electrocardiogram-based mortality prediction in patients with COVID-19 using machine learning.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2022
Same author

Enhanced PeriOperative Care and Health protection programme for the prevention of surgical site infections after elective abdominal surgery (EPO<sub>2</sub>CH): statistical analysis plan of a randomised controlled multicentre superiority trial.

Trials·2021

Area of Science:

  • Nuclear Medicine
  • Nephrology
  • Transplant Surgery

Background:

  • Radionuclide renal diagnostic studies are vital for evaluating kidney allograft function, particularly in the early post-transplant phase.
  • Quantitative parameters derived from radionuclide renograms help assess perfusion and function changes in kidney allografts.

Purpose of the Study:

  • To review quantitative parameters used for assessing renal graft condition in the early postoperative period.
  • To evaluate the clinical usefulness of frequently used quantitative methods for assessing early post-transplant graft function.

Main Methods:

  • Review of quantitative parameters for renal graft perfusion (e.g., activity appearance rate, integral activity ratio, vascular transit time).
  • Review of parenchymal uptake and excretion indices (e.g., accumulation index, uptake capacity, excretion index, elimination index).

Related Experiment Videos

  • Retrospective study evaluating global perfusion index (GPI), cortical perfusion index (CPI), vascular transit time, uptake capacity at 2 min (UC2), and elimination index (K3/20) in 43 patients with 157 technetium-99m mercaptylacetyltriglycine renograms.

    • Main Results:

    • Perfusion indices (GPI, CPI) were valuable for monitoring graft dysfunction improvement but could not differentiate acute tubular necrosis (ATN) from acute rejection (AR).
    • Parenchymal parameters (UC2, K3/20) differentiated stable graft function (SGF) from AR and ATN but could not separate AR from ATN.
    • Parenchymal parameters showed poor ability to detect graft function improvement.

    Conclusions:

    • Radionuclide scintigraphy is important for serial monitoring of renal transplant function.
    • Quantitative parameters derived from renograms cannot unequivocally differentiate between ATN and AR.
    • The primary value of these parameters lies in tracking dysfunction progression to guide therapeutic regimens.