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Insulin sensitivity in pre-eclampsia
R N Roberts1, J E Henriksen, D R Hadden
1Department of Obstetrics and Gynaecology, The Queen's University of Belfast, UK.
Objective:
To investigate whether pre-eclampsia is associated with an exaggeration of the insulin resistance seen in normotensive pregnancy.
Design:
Minimal model analysis of a frequently sampled intravenous glucose tolerance test to assess insulin sensitivity.
Setting:
Royal Maternity Hospital, Belfast.
Participants:
Eleven women with pre-eclampsia and 11 matched normotensive pregnant women.
Results:
Insulin sensitivity (S(I)) was increased in the group with pre-eclampsia compared with the normotensive women (mean [+/-SEM]: 2.6 [0.4] vs 1.6 [0.2] 10(-4) min(-1) per mU/L; P = 0.028). This was accompanied by a decrease in glucose effectiveness (SG) (1.1+/-0.1 vs 1.7+/-0.1 10(-2)min(-1), P = 0.006) in the pre-eclamptic women. In the normotensive group there was a significant inverse correlation between S(I)and mean arterial blood pressure (r = -0.65; P = 0.03), but no such relation existed in the group with pre-eclampsia.
Conclusions:
As with other forms of secondary hypertension, and unlike essential hypertension, the pathophysiology of pre-eclampsia is not associated with insulin resistance.