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Detection of HLA-A*24 null alleles by DNA typing methods
F Williams1, M D Curran, D Middleton
1Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast.
Tissue Antigens
|November 5, 1998
Abstract:
A number of cases have been identified (seven unrelated individuals from the Northern Ireland bone marrow donor registry and two family groups) where an HLA-A*24 allele fails to express the normal HLA-A24 antigen. Family information has revealed common haplotypes with respect to each non-expressed allele indicating that the occurrence of these mutations has been a recent event. Two methods for the clinical typing of these alleles have been evaluated--PCR-SSOP and PCR-SSCP analysis.