Related Experiment Video
Updated: Aug 18, 2026
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 31, 2013
Preselected biopsy for normal-appearing mucosa of superficial bladder carcinoma
N Miyao1, T Hisataki, A Takahashi
1Departments of Urology and Clinical Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Objectives:
We examined the incidence of positive findings (concomitant carcinoma in situ (CIS), frank carcinoma and dysplasia) for normal-appearing mucosal biopsies in superficial bladder carcinoma and the clinical outcome of patients with positive biopsy results.
Methods:
Eighty-four cases of newly diagnosed superficial bladder carcinoma, from whom biopsies of preselected cystoscopically normal-appearing mucosal tissue were taken at the time of initial treatment, were studied. Multivariate analysis by Cox's proportional hazards model was applied.
Results:
Twenty-seven percent of the patients with superficial bladder carcinoma showed positive biopsy results. Positive biopsy results independently influenced intravesical recurrence by Cox's proportional hazards model.
Conclusions:
Positive mucosal biopsy results are a significant indicator of intravesical recurrence in patients with superficial bladder carcinoma.
