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Effects of chocolate cyst fluid on endometrioma cell growth in culture
S Z Badawy1, V Cuenca, S Kumar
1Department of Obstetrics and Gynecology, State University of New York, Health Science Center, Syracuse 13210, USA.
Objective:
To evaluate the effect of chocolate cyst fluid on the proliferation of cultured human endometrioma cells and to assay the concentration of transforming growth factor-B1 in this fluid.
Design:
Controlled in vitro study.
Setting:
Department of Obstetrics and Gynecology, State University of New York Health Science Center.
Patient(S):
Five women with ovarian endometriomas.
Intervention(S):
Endometrioma tissue and chocolate fluid from five different patients were entered in this study.
Main Outcome Measure(S):
Endometrioma cell proliferation in culture with and without chocolate cyst fluid.
Result(S):
Chocolate cyst fluid increased the proliferation of endometrioma cells compared with controls. Also, high concentrations of transforming growth factor-B1 were found in cysts' fluid.
Conclusions:
Chocolate cyst fluid has a growth-enhancing effect on endometrioma cells. One promoting growth factor is transforming growth factor-B1.
