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A new simple cone-plate viscometer for hemorheology
1Equipe Hémorhéologie-Angiohématologie, Laboratoire d'Energétique et de Mécanique Théorique et Appliquée, UMR CNRS 7563, Faculté de Médecine, Vandoeuvre-lès-Nancy, France.
Clinical Hemorheology and Microcirculation
|November 7, 1998
Summary
A new automatic cone-plate viscometer (LBY-N6) accurately measures blood and plasma viscosity in clinical settings. It demonstrates good precision and reproducibility for routine viscosity testing at higher shear rates.
Area of Science:
- Biomedical Engineering
- Clinical Chemistry
- Rheology
Background:
- Accurate measurement of blood and plasma viscosity is crucial for clinical diagnostics.
- Existing viscometers may have limitations in speed or ease of use for routine clinical applications.
Purpose of the Study:
- To evaluate the performance of a new automatic cone-plate viscometer (LBY-N6) for clinical blood and plasma viscosity measurements.
- To assess the precision, reproducibility, and accuracy of the LBY-N6 compared to conventional viscometers.
Main Methods:
- The LBY-N6 viscometer was calibrated using standard oils (1.85-20.5 mPas).
- Blood and plasma viscosities were measured using the LBY-N6 and compared with Couette and capillary viscometers.
- Precision and reproducibility were assessed using standard deviations.
Main Results:
- The LBY-N6 showed relative errors <10% for standard oils at shear rates of 20-200 s(-1).
- Reproducibility was good (SD <3% in most cases), with minor discrepancies at low shear rates (<10 s(-1)).
- Blood viscosity measurements by LBY-N6 correlated well (<10% difference) with a conventional viscometer at high shear rates.
Conclusions:
- The LBY-N6 is a suitable routine tool for rapid clinical determination of blood and plasma viscosity.
- Accurate measurements are achievable at shear rates exceeding 20 s(-1).
- Observed differences at lower shear rates may relate to blood's viscoelastic and thixotropic properties.