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Constitutional balanced pericentric inversions of chromosomes X, 2, and 5 in myeloid malignancies
M J Mozziconacci1, H Sobol, N Philip
1Institut Paoli-Calmettes, Hematological Cytogenetics Laboratory, Marseille, France.
Cancer Genetics and Cytogenetics
|November 11, 1998
Abstract:
We report four cases of unrelated adult males carrying constitutive balanced pericentric inversions of chromosome X (one case), chromosome 2 (one case), and chromosome 5 (two cases) and presenting with myeloid malignancies. We discuss the potential contribution of these abnormalities to a background of susceptibility to hematologic malignancies.