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Updated: Aug 2, 2026

An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model
Published on: July 13, 2009
Comparison testing of the irritancy of children's liquid bubble bath using a modified human repeat insult patch test
N Y West1, J E Fitzpatrick, E M Jackson
1Dermatology Service, US Army Medical Activity, Heidelberg, Germany; the Department of Dermatology, University of Colorado Health Sciences Center, Denver, Colorado, USA.
Children's bubble baths vary in their potential to cause skin irritation. Sesame Street Fresh Apple Splash was found to be the least irritating in a study comparing nine popular brands.
Area of Science:
- Dermatology
- Pediatrics
- Consumer Product Safety
Background:
- Bubble baths are widely used by parents for young children.
- Some healthcare professionals express concerns regarding the use of bubble bath products for pediatric skincare.
- Understanding product safety is crucial for child well-being.
Purpose of the Study:
- To compare the skin irritancy potential of nine different children's liquid bubble bath formulations.
- To provide objective data to guide parental choices and professional recommendations.
Main Methods:
- A modified human repeat insult patch test (HRIPT) was employed.
- The study ranked the irritancy of nine bubble bath preparations.
- Evaluations included erythema, scaling, and fissuring at test sites.
Main Results:
- Significant variations in irritancy were observed among the nine tested bubble bath products.
- Sesame Street Fresh Apple Splash bubble bath demonstrated the lowest level of erythema, indicating minimal irritation.
- Individual product formulations impact their dermatological effects.
Conclusions:
- Children's bubble bath brands differ in their irritancy profiles.
- Dermatologists and pediatricians can offer informed recommendations to parents regarding bubble bath selection.
- Evidence-based guidance can help minimize potential skin reactions in children.
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