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BEHAB/brevican: a brain-specific lectican implicated in gliomas and glial cell motility
S C Gary1, G M Kelly, S Hockfield
1Section of Neurobiology, Yale University, New Haven, Connecticut 06520-8001, USA. sydney.gary@yale.edu
Current Opinion in Neurobiology
|November 13, 1998
Abstract:
Several recent findings have advanced our understanding of the composition and function of the brain extracellular matrix (ECM). BEHAB/brevican, a recently identified CNS-specific proteoglycan, is a component of the brain ECM and is upregulated during glial cell motility. It is expressed at high levels during development, in response to injury, and in primary brain tumors. Cleavage of the BEHAB/brevican protein may increase invasion of tumor cells.