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[Anti-tumor effects of ailing-1 on human megakaryoblastic leukemia cells]
Abstract
Objective:
To evaluate the anti-cancer effect of Ailing-1 on human megakaryoblastic leukemia cells in culture.
Methods:
Using living cell counting, 3H-TdR incorporation and clonal proliferation assay.
Results:
Ailing-1 has various cytotoxicity on cell level, DNA synthesis and clone proliferation and shows good does-effect relation. The ED50 of Ailing-1 is greater than that of homoharringtonine through three different methods, consistent with the clinical result. Drug resistance has not been found.
Conclusion:
Ailing-1 is a promising anti-tumor drug.